Arsene Wenger will go into the north London derby at White Hart Lane without his side’s top scorer, who is not fully recovered from a hamstring problem.
“Alexis is not ready,” Wenger told the Arsenal website. “He is not far away, the Leicester game (on Tuesday) is a possibility. He is of course very difficult to keep quiet! He is training but it’s light training.”
Arsenal beat Aston Villa 5-0 without the Chilean, and the only change to the squad on duty last weekend will see Danny Welbeck return after more than a month out.
Welbeck has not played since December 28, when his goal helped earn a 2-1 win at West Ham, but his thigh injury has now healed.
Wenger said he expects Jack Wilshere back in full training next week after a long-term ankle injury, but there was no mention of a photograph in Thursday’s newspapers which appeared to show the midfielder holding a shisha pipe while on a night out.
January signing Krystian Bielik, meanwhile, will play for the club’s U21 side at Newcastle on Monday alongside Serge Gnabry, the German forward who has been out since March.