The Thomas Tuchel side put up a stunning performance to outplay the home side as goals from Rudiger, Kante and Pulisic sealed all 3 points for the League leaders.
Ndidi started off the game and played all through the game while Iheanacho came in 46 minutes into second half to replace Lookman.
The Nigerian stars returned to action after the international break only to display a poor performance for the Brendan Rodgers side.
The Blues should have score more to make it five goals, but Pulisic, Cullum Odoi and Reece James were all denied scoring opportunities as their goals were ruled out for offside.
Chelsea’s lead at the top of the Premier League table has extended to six points after the 3-0 away win.